منابع مشابه
Oxygen Modulates Prostacyclin Synthesis
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Mefloquine, as a racemic mixture, is used for the treatment and prophylaxis of malaria. Stereoselective pharmacodynamic and pharmacokinetic differences has been observed for mefloquine. In this study a modified stereoselective HPLC method is presented for determination of mefloquine (MFQ) enantiomers in whole blood. The assay involved liquid-liquid extraction of MFQ from biological fluids with ...
متن کاملInhibition of Vascular Endothelial Cell Prostacyclin Synthesis
Vascular endothelial cells (EC) play an active role in the synthesis and assembly of components of the fibrinolytic system and the generation of the major fibrinolytic protease plasmin. However, the reciprocal effects of plasmin on EC function have not been previously examined. We have studied the actions of plasmin on the production of prostacyclin (PGI2) by cultured human umbilical vein (HUVE...
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The slow-reacting substances (SRS) consist of leukotrienes C, D, and E (LTC, -D, -E) 1 and are derived from the lipoxygenase pathway of arachidonic acid (20:4) metabolism. In examining possible mechanisms for the vasoactive effects of SRS (1-4), we found that cultures o f human endothelial cells release the vasodilatory agent, prostacyclin, on exposure to 10 -9 to 10 -6 M LTC (5). Previous repo...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1987
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.18.83